Bioavailability of D4 after inhalation and implantation exposure to silicones.
نویسندگان
چکیده
منابع مشابه
Bioavailability of D4 after inhalation and implantation exposure to silicones.
In the November 2001 issue of EHP, Luu and Hutter (1) described a physiologically based pharmacokinetic (PBPK) model for the bioavailability of octamethylcyclotetrasiloxane (D4) following exposure to D4 by inhalation and implantation. In this paper the authors developed a PBPK model that used a very limited data set obtained after either single or repeated intravenous (iv) administration of D4 ...
متن کاملBioavailability of octamethylcyclotetrasiloxane (D(4)) after exposure to silicones by inhalation and implantation.
We developed a physiologically based pharmacokinetic (PBPK) model to predict the target organ doses of octamethylcyclotetrasiloxane (D(4)) after intravenous (IV), inhalation, or implantation exposures. The model used (14)C-D(4) IV disposition data in rats to estimate tissue distribution coefficients, metabolism, and excretion parameters. We validated the model by comparing the predicted blood a...
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The retention, distribution, metabolism, and excretion of [C]octamethylcyclotetrasiloxane (D4) were studied in Fischer 344 rats after single and multiple exposures to 7, 70, or 700 ppm [C]D4. Subset groups were established for body burden, distribution, and elimination. Retention of inhaled D4 was relatively low (5–6% of inhaled D4). Radioactivity derived from [ C]D4 inhalation was widely distr...
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BACKGROUND Benzalkonium chloride (BAC) is a quaternary ammonium compound (QAC) with a C8 to C18 chain length of alkyl groups. Since BAC exerts toxic effects on microorganisms, it has been used as an effective germicide and preservative, mostly in cosmetic industry and medicine. However, the toxic potential of BAC may be hazardous to humans, due to the common use of preparations containing BAC a...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2002
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.110-a442